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429 ± 3.804 s vs. 238.2 ± 17.42 s; P less then 0.0001), shortened the emergence time after deep isoflurane anesthesia (109.5 ± 13.59 s vs. 213.8 ± 21.77 s; P = 0.0023), and increased the paw withdrawal latency in a hotplate test (11.45 ± 1.185 s vs. 8.767 ± 0.7775; P = 0.0317). The structural details of orexin fibers established the neuroanatomic basis for studying the role of orexin in anesthesia and analgesia.[This corrects the article DOI 10.3389/fncel.2022.837650.].Noradrenergic neurons in the locus coeruleus (LC) release noradrenal