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The pandemic of coronavirus illness 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to an unprecedented general public wellness challenge globally. Despite urgent and extensive international efforts, the current research is inconclusive about the medicines employed for the treating COVID-19. . Three investigators considered the quality associated with studies. . The info of 6,782 (HCQ group, 3623; HCQ + AZ group, 1,020; con