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Knowing the importance of QoL and its related factors, it is necessary to propose health activities and strategies for the all-around improvement of these patients. Recent researches suggest that there is a relationship between the pathogenesis of depression and serum Brain Derived Neurotrophic Factor (BDNF) levels. Therefore, the purpose of this clinical trial was to determine effect of magnesium supplementation on serum Level of BDNF, magnesium and depression status in patients with depression. A double blind randomized clinical tria