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The incidence is greatest in teenagers, and also the most common websites would be the distal femur, proximal tibia and proximal humerus metaphyseal. Doxorubicin could be the first-line chemotherapeutic representative for the treatment of osteosarcoma, nonetheless it has many complications. Cannabidiol is a non-psychoactive plant cannabinoid cannabinol (CBD) that is shown to be efficient against osteosarcoma; however, the molecular targets and mechanisms of CBD activity in osteo