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The GO-DOX significantly increased the ATG5 (3.1-fold, p 0.0001), caspase 3 (4.7-fold, p 0.0001), and Bax (4.3-fold, p 0.0001) gene expression. The GO-DOX exerted anticancer effects against the HCT-116 cells via inducing the apoptosis and autophagy. The GO-DOX exerted anticancer effects against the HCT-116 cells via inducing the apoptosis and autophagy. We provided a study on homeologous gene evolution of homeologous genes by comparing Brassica genomes. Polyploidy has played fundamental roles during the evolution of plant
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