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However, none of the studied combinations were bactericidal against the K11R2 isolate. CONCLUSIONS In conclusion, the combinations used in this study showed synergy against NDM and KPC producing isolates, but, given the bactericidal activity, the combinations of PMB / MEM and PMB / AMK were the most active only against one isolate. It also can be concluded that the antimicrobials to which the bacteria were resistant could be part of these combinations. OBJECTIVES Fungal pathogens pose a serious threat to public health. Widespread an