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Adult ADHD and Comorbid Disorders Many people suffering from ADHD suffer from comorbid disorders, such as major depression (Kessler et al 2006). Many depressed patients do not respond well to medications and may be able to benefit from therapy. Treatments that are most effective in reducing the symptoms of ADHD are those that boost and balance levels of specific brain chemicals called neurotransmitters. The stimulants methylphenidate and amphetamine are often prescribed. Medic