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ications, fracture, infection, or revision. The inclusion of seven surgeons increases the generalizability of these results. Cite this article Bone Joint J 2021;103-B(7 Supple 38-45. Aseptic loosening is a leading cause of uncemented arthroplasty failure, often accompanied by fibrotic tissue at the bone-implant interface. A biological target, neutrophil extracellular traps (NETs), was investigated as a crucial connection between the innate immune system's response to injury, fibrotic tissue development, and proper bone healing. Pre