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The current in vitro research examined cangrelor's ability to restrict heparin-induced platelet aggregation when you look at the existence of anti-PF4/Hep Abs. METHODS Platelet-poor plasma (PPP) from 30 customers with functional anti-PF4/Hep Abs ended up being blended with platelet-rich plasma (PRP) from 5 healthy donors.Light transmission aggregometry was made use of to measure platelet aggregation after adding 0.5 IU·mL of heparin (HIT) into the plasma, and also this was compared w