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etabolically unhealthy despite not being obese were at highest risk in our cohort.President Richard Nixon signed the National Cancer Act into law on December 23, 1971. In the 50 years since then, researchers have made tremendous strides in understanding, preventing, and treating cancer, but much remains to be done-requiring greater investment in the NCI and the Cancer Moonshot.Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors characterized by minimally effective genotype-targeted therapies. Recent ad