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What Happens If ADHD is Left Untreated in Adults? Adults suffering from ADHD may experience a variety of issues if the condition goes untreated. These issues can affect relationships, work, and mental health. Adults who suffer from untreated ADHD generally have low self-esteem, and a pessimistic outlook on the world. They may feel as if they're failing at work and at home. Inattention and lack of Focus Finding it difficult to stay focused at times is normal, especially after a long day