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These results show that XIST has functions beyond X chromosome inactivation and suggest that XIST can subscribe to sex-specific differences underlying inflammatory response by attenuating intense irritation in women.It is well-established that Lysine-specific demethylase 1 (LSD1, also known as KDM1A) roles as a lysine demethylase canonically acting on H3K4me1/2 and H3K9me1/2 for regulating gene phrase. Although the finding of non-histone substrates methy