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Notably, chronic exposure of aortic rings to endorepellin for 7-9 days markedly suppressed vessel sprouting, an angiostatic effect that was rescued by blocking PERK kinase activity. Our findings unravel a mechanism by which an extracellular matrix protein evokes stress signaling in endothelial cells that leads to angiostasis. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.Timely resolution of bacterial infections critically depends on phagocytosis of invading pathogens by polymorphonuclear n
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