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The combination rutin-diclofenac showed an interaction index of 0.17. In the in vivo assay, the combinations of rutin-diclofenac (interaction index = 0.195) and rutin-ketorolac (interaction index = 0.408) displayed synergistic effects, and the combination rutin-paracetamol exhibited additive effects. Rutin produces synergistic effects with paracetamol and NSAIDs in in vitro and in vivo assays. Rutin produces synergistic effects with paracetamol and NSAIDs in in vitro and in vivo assays. To evaluate plasma dopamine and catecholamine leve