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05). No differences in the failure patterns were found among groups. NaOCl+HEBP had no detrimental effect on the POBS of CSBC. The mixture of sodium hypochlorite and etidronic acid may be considered as an alternative irrigant when treating root perforations. The mixture of sodium hypochlorite and etidronic acid may be considered as an alternative irrigant when treating root perforations.This article presents secondary headache syndromes caused by life-threatening disease as well as symptomatic headaches requiring immediate treatment to prevent