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Results were similar when restricting to disease resulting in at most an ambulatory clinic or emergency department visit. CONCLUSIONS These results support the effectiveness of rotavirus vaccination in protecting U.S. children from mild to moderate as well as severe disease. Our findings are also useful to show the effectiveness of rotavirus vaccination against qRT-PCR-defined illness. Published by Oxford University Press for the Infectious Diseases Society of America 2020. This work is written by (a) US Government employee(s) and is in the