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Mixed medullary and follicular cell-derived thyroid carcinoma (MMFTC) is a rare primary thyroid carcinoma with morphologic and immunophenotypic evidence of admixed parafollicular and follicular cell-derived tumor populations within the same tumor. We herein present the fine-needle aspiration biopsy (FNA cytology of a case of MMFTC that was diagnosed histologically and discuss potential clues to the diagnosis for cytologists. We also provide a literature review of this uncommon primary thyroid tumor. The patient was a 47-year-old man