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There were positive correlations between monocytes and eosinophils (r=0.99), plasma cells and regulatory T cells (r=0.88), activated mast cells and dendritic cells (r=0.75) in NPC, while M1 macrophages were negatively correlated with memory B cells (r=-0.71) and activated memory CD4+T cells (r=-0.63). In addition, GO of differential genes in NPC was mainly enriched in the function related to ciliary movement, and KEGG was mainly enriched in the pathway related to cytochrome P450. CCDC39 was a key gene in NPC, which was highly expressed