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could facilitate inappropriate use. Conclusion Inappropriate antibiotic use was high and influenced by out-of-pocket payment for healthcare, seeking healthcare outside health centers, pharmacies, and buying antibiotics in installments due to cost. To improve appropriate antibiotic use, there is the need for ministry of health and healthcare agencies in Ghana to enhance healthcare access and healthcare insurance, and to provide affordable antibiotics. Copyright © 2020 Afari-Asiedu, Oppong, Tostmann, Ali Abdulai, Boamah-Kaali, Gyaase, Agy