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Finding the Best ADHD Medication For Adults Stimulants, such as methylphenidate and amphetamine, (Vyvanse), quickly work to regulate brain chemicals. These drugs can lead to a loss of appetite, sleep problems, weight changes and tics in some people. Atomoxetine, along with certain antidepressants such as bupropion, are nonstimulants that work slowly to treat ADHD symptoms. They boost a chemical in the brain called norepinephrine to enhance concentration and control of
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