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In this review, we discuss the broad protective vs. pathogenic roles of NETs, explanatory factors that could lead to an increase in NET formation in IBD and how NETs may contribute to gut inflammation and IBD-related complications. Finally, we summarise therapeutic opportunities to target NETs in IBD.The first 1000 days from conception are a sensitive period for human development programming. During this period, environmental exposures may result in long-lasting epigenetic imprints that contribute to future developmental trajectories.

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Spiking activity of individual neurons can be separated from the acquired multi-unit activity with spike sorting methods. Processing the recorded high-dimensional neural data can take a large amount of time when performed on general-purpose computers. In this paper, an FPGA-based real-time spike sorting system is presented which takes into account the spatial correlation between the electrical signals recorded with closely-packed recording sites to cluster multi-channel neural data. The system uses a spatial window-based version of