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How Does Medication For ADHD Work? are among the most frequently prescribed ADHD medicines. They boost the levels brain chemicals, such as dopamine and norepinephrine. They include methylphenidate (Ritalin, Concerta), amphetamine and dextroamphetamine (Adderall) and lisdexafetamine (Vyvanse). Doctors often prescribe these in long-release formulations that last for six to eight hours or more. This minimizes ups and downs as the medicine wears off. The majority of people notice a decrease in s