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The Most Effective ADHD Medication For Adults Most ADHD medications fall into two categories: stimulants and non-stimulants. The stimulants such as methylphenidate (Provigil) and amphetamines work by increasing activity in parts of the brain that regulate attention and behaviour. Non-stimulants like guanfacine the atomoxetine and clonidine work slower than stimulants, however they can help improve concentration and attention as well as impulsivity. They also appear to reduce anxiety, w
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