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The Importance of a Gas Safety Certificate For Landlords and Letting Agents Gas safety checks are essential for any landlord or letting representative. They make sure that all gas appliances are safe to use and that a CP12 has been provided. It is a legal requirement for landlords to have a gas safety check performed every year. This is normally evidenced by a CP12. It likewise helps to avoid carbon monoxide gas poisoning, which can be fatal within hours. What is a Gas Safety Certifica

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05). Interference of ESR2 caused significant reduction in the expressions of ER stress-related proteins and apoptosis-related proteins, up-regulated the genes related to cell proliferation, and increased intracellular pERK/ERK ratio in C28I2 cells. The effect of E2 binding to ERβ, which promoted the expressions of ER stress associated proteins and apoptosis related proteins, was obviously antagonized by treatment of the cells with U0126. The binding of E2 to ERβ promotes ER stress and apoptosis in human chondrocytes by activating ERK