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le isoform, we studied excitatory climbing fiber synaptic function onto Purkinje cells in Cacna2d2 knockout mice. Using optical and electrophysiological analysis, we provide a detailed description of the changes in Purkinje cells lacking α2δ-2, and provide a comprehensive mechanistic explanation for how functional synaptic phenotypes contribute to the altered cerebellar output. Copyright © 2020 the authors.Hair cells in both the auditory and vestibular systems receive efferent innervation. A number of prior studies have indicated that ef
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