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Increased miR‑145‑5p appearance inhibited the proliferation and colony formation ability of osteosarcoma cells, and induced G1 phase arrest. Furthermore, mice injected with tumor cells overexpressing miR‑145‑5p exhibited smaller tumors than those within the control group. Further examination revealed that miR‑145‑5p binds to and decreases the appearance of E2F3. In inclusion, the mRNA levels of E2F3 were adversely associated with miR‑145‑5p in osteosarcoma tissues, and

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