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The rural subgroup was more likely to present at the time of diagnosis with a lower grade (p0.001) and an earlier stage (p0.001). Rural populations demonstrated superior overall survival (p0.001), whereas urban populations were more likely to die as a result of their OSCC (p0.001). After adjusting for all patient-specific factors, urban status still yielded a poorer disease prognosis. Living in rural areas is associated with better prognosis and long-term survival in patients with OSCC. Further studies are needed to better