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These conceptual advances raise the possibility that successful targeting of m1 G37-tRNA methylation can provide new approaches for treating acute and chronic infections caused by Gram-negative bacteria. This article is categorized under Translation Translation Regulation RNA Processing RNA Editing and Modification RNA Structure and Dynamics Influence of RNA Structure in Biological Systems.Aims Employers in the United States incur substantial costs associated with substance use disorders. Our goal was to examine the effectiveness of