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2; p = 0.011), of older age (OR 1.1; p = 0.001), and with previous use of ACE inhibitors (OR 4.8; p = 0.026). In COVID-19 patients, late intubation, Pafi 100, older age, and previous ACE inhibitors use were associated with increased ICU mortality. In COVID-19 patients, late intubation, Pafi less then 100, older age, and previous ACE inhibitors use were associated with increased ICU mortality. The aim of this study was to evaluate the capability of features extracted from photoplethysmography (PPG) based Pulse Rate Variability (PRV) t