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Moreover, knock down of ELF3 increased S139 phosphorylated histone H2AX (γH2AX), and inhibited homologous recombination activity down-regulation of DNA repair protein RAD51 homolog 1 (RAD51), thus showing deficiency in DNA damage repair. Over-expression of ELF3 could up-regulate phosphorylation of AKT (Protein kinase , while knock down of ELF3 regulated homologous recombination-mediated DNA repair down-regulation of phosphorylation of AKT. Knock down of ELF3 revealed homologous recombination deficiency AKT signaling pathway, and syntheti