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iCCA with DPM pattern had the highest vascular densities (mean microvascular density,140/mm2; arterial vessel density, 18.3/mm2). Increased CLC component was correlated with longer overall survival time (r =0.44, P =0.006). Pure SBD tumors had a lower 5-year overall survival rate, compared with MF-iCCA with CLC pattern (30.5% vs. 72.4%, P = 0.011). MF-iCCAs comprise four histological subtypes. Given their sharing some driver gene alterations, indicating they can have a common cell origin, SBD, CLC and DPM subtypes, however, differ in cel