https://www.selleckchem.com/pr....oducts/sch-527123.ht
Compared with normal chondrocytes, OA chondrocytes had high expression of COL I protein and low expression of COL II protein. The expression levels of MAPK-14, PTPRC and PTPN12 in OA chondrocytes were significantly higher than the expression levels of B9D1 in normal chondrocytes. Moreover, the inflammatory necrosis of OA chondrocytes was increased compared with the normal chondrocytes by propidium iodide staining. The high expression of MAPK-14 works as a promoter of chondrocytes death and an important signal of the osteoarthritis pr

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