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Statistical analysis was done by using Microsoft Excel. There was an abnormal gene expression of p53 in all grades of the breast tumors. Non-significant (p0.05) difference of down and up regulation of p53 in different grades of breast tumor was found. However, as a whole up-regulation was more than down-regulation with significant difference (p0.0011). The abnormal expression of p53 shows that there are some genetic and epigenetic factors which are the primal cause of an abnormal gene expression. It is recommended that perform n
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