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The novel SimSearch method provides innovative support for effective genome-wide pattern search and visualization; its relevance and practical usefulness is demonstrated through a number of significant use cases of biological interest. The SimSearch IGB plugin, documentation, and code are freely available at https//deib-geco.github.io/simsearch-app/ and https//github.com/DEIB-GECO/simsearch-app/ . The novel SimSearch method provides innovative support for effective genome-wide pattern search and visualization; its relevance and practica