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Diabetes has been reported as a risk factor for hepatocellular carcinoma (HCC) in population based studies but there are controversial data in patients with cirrhosis. Otherwise, metformin could have a protective role in HCC development. The aim of this study was to know the influence of diabetes on the risk of developing HCC in patients with alcohol- and hepatitis C virus (HCV)-related cirrhosis. We analyzed 982 Caucasian patients with alcoholic or HCV cirrhosis included from 1992 to 2014 in a HCC surveillance program and prospectively