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AV replacement was required in 2 patients. Mean Lipoprotein(a) concentration was 42.4 mg/dl, 38% had 50 mg/dl. There was no overt correlation of AV pathologies with other ASCVD complications, or Lipoprotein(a) concentration. Physicochemical elimination of LDL particles by LA appears indispensable for patients with bi-allelic familial hypercholesterolemia and severe hypercholesterolemia to maximize the reduction of LDL-C. In conclusion, in this rare patient group regular assessment of both the AV, as well as all arteries accessible b

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Bickerstaff brainstem encephalitis, Miller-Fisher syndrome and Guillain-Barré syndrome are related conditions and are now considered as part of a continuous clinical spectrum. In this report, we describe the case of a 24-year-old female patient showing paraparesis rapidly evolving into flaccid tetraparesis, areflexia, ophthalmoplegia, drowsiness, cognitive impairment and memory loss leading to the diagnosis of Bickerstaff brainstem encephalitis and Guillain-Barré syndrome overlap. With this example, we emphasize the importance of in