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Treatment For ADHD The most effective treatment options for add are medications and psychosocial therapy (psychotherapy). The drugs include stimulants such as methylphenidate, amphetamine, and atomoxetine. They may also be non-stimulants like clonidine or guanfacine. Patients with active issues with addiction should not take stimulant medications. However, those who are in stable remission might look into them. Combination treatment with antidepressants (particularly SSRIs