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To report the clinical profile associated with G60 and I60 over a 4-year prospective observational period in 2 large cohorts of adult patients with CF. 319 patients were included (210 Canadian and 119 French) and classified according to their inclusion G60 (≥ or 11.1 mmol/L) and the median inclusion I60 (≥ or 24 mU/I). Forced expiratory volume in 1 second (FEV1), body mass index (BMI) were collected on OGTT days. Linear mixed regression models were used to assess the effect of G60 and I60. High G60 was not associated to a lower