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Knowledge of the pharmacophore may permit future development of positive allosteric modulators to increase the healing efficacy of PTH1R agonists. Copyright © 2019 American Chemical Society.G protein-coupled receptors (GPCRs) form the greatest family of membrane proteins involved with signal transduction. Because of their capability to control many mobile responses and their particular dysregulation becoming involving many diseases, GPCRs stay an integral therapeutic target for se
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