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001), testes weights (p less then 0.05) and testis sizes (p less then 0.001). Furthermore, mRNA expressions of ESR2 (p less then 0.05), CYP19A1 (p less then 0.001), SOX9 (p less then 0.001) and BRD7 (p less then 0.001) in testis of mice were increased in the LGE group. Similarly, HGE treatment increased mRNA expressions of ESR2 (p less then 0.05) and CYP19A1 (p less then 0.001). However, mRNA expressions of SOX9 and BRD7 were decreased significantly in the HGE group (p less then 0.001). Meanwhile, higher ratio apoptotic germ cell