https://www.selleckchem.com/pr....oducts/pf-04965842.h
Polyglutamine (polyQ) diseases are dominant neurodegenerative diseases caused by an expansion of the polyQ-encoding CAG repeats in the disease-causing gene. The length of the CAG repeats is the major determiner of the age at onset (AO) of polyQ diseases, including Huntington's disease (HD) and spinocerebellar ataxia type 3 (SCA3). We set out to identify common genetic variant(s) that may affect the AO of polyQ diseases. Three hundred thirty-seven patients with HD or SCA3 were enrolled for targeted sequencing of 583 genes implicated
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