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We demonstrated that the transduction of Wnt11 into mesenchymal stem cells (MSCs) (MSC ) promotes these cells differentiation into cardiac phenotypes. In the present study, we investigated the paracrine effects of MSC on cardiac function and angiogenesis. Conditioned medium was collected from MSC (CdM ) and their control cells (CdM ). CdM , especially obtained from MSC exposed to hypoxia, significantly promoted human umbilical vein endothelial cells (HUVECs) migration and increased capillary-like tube (CLT) formation, which was blocked