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Both bench and bedside investigations have challenged the supportive role of Hedgehog (Hh) activity in the progression of colorectal cancers, thus raising a critical need to further deeply determine the contribution of Hh to the growth of colorectal cancer. Combining multiple complementary means, including in vitro and in vivo inflammatory colorectal cancer models, and pathological analysis of clinical colorectal cancer patients samples. We report that colorectal cancer cells hijack prostaglandin E2 (PGE2) to non-canonically promote Hh t

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1 volume % APG-Ph foam with 3.5 mg/l nZVI for desert, coastal, and clay soil is 94.6, 95.3, and 57.5%, respectively. The optimum concentrations of APG-Ph and nZVI are found to be 0.98 volume % and 0.8 mg/l, respectively. Validation of this optimal condition experimentally results in highest removal efficiency of 98.3, 97.2, and 75.9% for desert, coastal, and clay soil respectively. This is in good agreement with the predicted values by RSM (98.67, 97.57, and 76.85%). The maximum diesel removal efficiency predict