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50 (95% CI 1.13-1.97)] (E-value for point estimate=2.37) and during both trimesters of pregnancy [RR 1.41 (95% CI 1.03-1.89)] (E-value for point estimate=2.17). However, we found insufficient statistical evidence for an association between paternal smoking during pregnancy and risk of tobacco smoking in offspring [RR 1.18 (95% CI 0.84-1.67)]. Maternal prenatal tobacco exposure was associated with an increased risk of tobacco smoking in offspring at the age of 17years. Tobacco smoking cessation at the early stages of