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Phosphodiesterase 10 (PDE1 inhibitors have received much attention as promising therapeutic agents for central nervous system (CNS) disorders such as schizophrenia and Huntington's disease. Recently, a hit compound 1 with a novel chromone scaffold has shown moderate inhibitory activity against PDE10A (IC50 = 500 nM). Hit-to-lead optimization has resulted in compound 3e with an improved inhibitory activity (IC50 = 6.5 nM), remarkable selectivity (95-fold over other PDEs), and good metabolic stability (RLM t1/2 = 105 min) by using an

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Why It's Important to See a Doctor Premature ventricular contractions (PVCs) are a kind of irregular heartbeat. These extra beats are usually not dangerous, and they can disappear by themselves. To diagnose PVC doctors listen to your heartbeat and look for other vital signs. They may order a Holter Monitor which captures the electrical impulses of your heart over a span of 24 to 48 hours. They can also request blood tests to check your thyroid hormones and electrolyte levels. Diagnosis PVCs are caused by electrical impulse