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The negative predictive values for v2 and v3 were 92% and 100%, correspondingly. CONCLUSIONS The PPV of an HRM result on ThyroSeq v3 was low for malignancy or NIFTP, and the PPV for neoplasm had been greater. RAS-type mutations had been probably the most frequently identified in both benign and malignant nodules. Thyroseq v3 had a lower PPV for both malignancy/NIFTP and neoplasm than v2 but didn't produce any false-negative outcomes. © 2020 American Cancer Society.A cons