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HFNO reduced the proportion of patients experiencing SpO2 less then 94% (43.2% vs. 89.7%, P less then 0.001) and SpO2 less then 90% (16.2% vs. 69.2%, P less then 0.001). The FB was interrupted 11 times in 9 patients in the LFNO group, whereas there were no interruptions in the HFNO group. There were no differences in patient and bronchoscopist satisfaction scores between groups, anesthesiologists had higher satisfaction scores when using HFNO (P less then 0.001). CONCLUSION Hypoxia occurred less commonly in postlung transplant patients r