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In PS-quintile adjusted analysis, those on newer DMTs had lower relapse rate than those on injectables (rate ratio 0.45, 95%CI 0.29-0.70, p less then 0.001; rate difference 0.27, 0.14-0.40, p=0.004). One would need to treat with newer over injectable DMTs for 3.7 person-years to prevent one relapse. Those started on newer DMTs had lower rate of new/enlarging T2 (HR 0.51, 0.36-0.72, p less then 0.001) and gadolinium-enhancing lesions (HR 0.38, 0.23-0.63, p less then 0.001) than those on injectables. INTERPRETATION Initial treatment of pe
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