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Linear regression analysis showed that FT4 but not FT3 and free T3T4 was negatively associated with HOMA-β no matter in general population or T2DM patients, which was independent of age, BMI, smoking, hypertension and lipid profiles. FT4 is independently and negatively associated with islet beta-cell function in euthyroid subjects. Thyroid hormone even in reference range could play an important role in the function of pancreatic islets.The contamination status of H5 avian influenza viruses and distribution of subtypes of H5N1 and H5N6 in