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However, ε4 carriers showed faster progression than non-carriers regardless of kinds of AD biomarkers' trajectories. Our temporal trajectory models illustrate that there is a distinct progression pattern of AD biomarkers depending on sex and genotype. In this regard, our models will be able to contribute to designing personalized treatment and prevention strategies for AD in clinical practice. Our temporal trajectory models illustrate that there is a distinct progression pattern of AD biomarkers depending on sex and APOE genotype. I